基于人工神经网络的智能化架空线路应变快速解调方法北大核心

为了提高智能化光纤复合架空线路态势感知的实时性,将人工神经网络方法应用于光纤沿线应变解调,确定了神经网络的结构。编程实现了基于洛伦兹模型的最小二乘谱拟合方法和神经网络方法,采用不同信噪比和布里渊频移的布里渊谱训练神经网络,将它们应用于某光纤复合架空线路沿线光纤应变的测量,从不同角度比较了两种方法的计算结果。计算结果表明,神经网络方法能有效获得光纤沿线的布里渊频移进而获得应变,具有与谱拟合方法相似的准确性,但应变解调时间仅约为谱拟合方法的1/20000。研究结果为提高智能光纤复合架空线路态势感知的实时性提供了参考。     

Role of NEU3 Overexpression in the Prediction of Efficacy of EGFR-Targeted Therapies in Colon Cancer Cell Lines

The epidermal growth factor receptor (EGFR), through the MAP kinase and PI3K-Akt-mTOR axis, plays a pivotal role in colorectal cancer (CRC) pathogenesis. The membrane-associated NEU3 sialidase interacts with and desialylates EGFR by promoting its dimerization and downstream effectors’ activation. Among the targeted therapies against EGFR, the monoclonal antibody cetuximab is active only in a subgroup of patients not carrying mutations in the MAP kinase pathway. In order to better understand the EGFR-NEU3 interplay and the mechanisms of pharmacological resistance, we investigated the role of NEU3 deregulation in cetuximab-treated CRC cell lines transiently transfected with NEU3 using Western blot analysis. Our results indicate that NEU3 overexpression can enhance EGFR activation only if EGFR is overexpressed, indicating the existence of a threshold for NEU3-mediated EGFR activation. This enhancement mainly leads to the constitutive activation of the MAP kinase pathway. Consequently, we suggest that the evaluation of NEU3 expression cannot entirely substitute the evaluation of EGFR because EGFR-negative cases cannot be stimulated by NEU3. Furthermore, NEU3-mediated hyperactivation of EGFR is counterbalanced by the administration of cetuximab, hypothesizing that a combined treatment of NEU3- and EGFR-targeted therapies may represent a valid option for CRC patients, which must be investigated in the future.     

超级计算机网络引导技术研究与分析

针对超级计算机系统中网络引导时间开销大的问题，提出网络引导分布算法是影响网络引导性能的主要因素之一，是优化网络引导性能的主要方向的观点。首先，分析了影响大规模网络引导性能的主要因素；其次，结合一种典型超级计算机系统，分析了超节点循环分布算法（SCDA）和插件循环分布算法（BCDA）的网络引导数据流拓扑结构；最后，量化分析了这两种算法对各个网络路径段的压力和可获得的网络性能，发现BCDA性能是SCDA性能的1~20倍。通过理论分析和模型推导发现，在计算节点和引导服务器之间使用更细粒度的映射算法可以在引导部分资源时使用尽量多的引导服务器，减少对局部网络资源的过早竞争，提升网络引导性能。     

Balancing of parallel U-shaped assembly lines

A new hybrid assembly line design, called parallel U-shaped assembly line system, is introduced and characterised along with numerical examples for the first time. Different from existing studies on U-shaped lines, we combine the advantages of two individual line configurations (namely parallel lines and U-shaped lines) and create an opportunity for assigning tasks to multi-line workstations located in between two adjacent U-shaped lines with the aim of maximising resource utilisation. Utilisation of crossover workstations, in which tasks from opposite areas of a same U-shaped line can be performed, is also one of the main advantages of the U-shaped lines. As in traditional U-shaped line configurations, the newly proposed line configuration also supports the utilisation of crossover workstations. An efficient heuristic algorithm is developed to find well-balanced solutions for the proposed line configurations. Test cases derived from existing studies and modified in accordance with the proposed system in this study are solved using the proposed heuristic algorithm. The comparison of results obtained when the lines are balanced independently and when the lines are balanced together (in parallel to each other) clearly indicates that the parallelisation of U-shaped lines helps decrease the need for workforce significantly.     

A novel fast distance relay for series compensated transmission lines

This paper presents a fast distance relay for series compensated transmission lines based on the R–L differential-equation algorithm using the theory of equal transfer process of transmission lines. The measuring distances based on the proposed algorithm can fast approach the actual value of fault distance when a fault occurs in front of the series capacitor. When a fault occurs behind of the series capacitor, the fault loop, including the series capacitor, does not match the R–L transmission line model, so the measuring distances fluctuate severely. Based on this, the relative position of the fault with respect to the series capacitor can be judged effectively according to the fluctuation range of the measuring distances, and the accurate fault location can be obtained fast. A variety of PSCAD/EMTDC simulation tests show that the new relay has fast operating speed and high accuracy when applied to the long series compensated transmission lines.     

Optimal cost design of flow lines with reconfigurable machines for batch production

Modular reconfigurable machines offer the possibility to efficiently produce a family of different parts. This paper formalises a cost optimisation problem for flow lines equipped with reconfigurable machines which carry turrets, machining modules and single spindles. The proposed models take into account constraints related to: (i) design of machining modules, turrets, and machines, (ii) part locations, and (iii) precedence relations among operations. The goal is to minimise equipment cost while reaching a given output and satisfying all the constraints. A mixed integer programming model is developed for the considered optimisation problem. The approach is validated through an industrial case study and extensive numerical experiments.     

基于CATIA的桥式起重机司机室人机工程设计

为改善桥式起重机司机室作业环境,提高作业舒适度,对桥式起重机司机室的布局及各尺寸结合人机工程学相关理论进行了分析,并给出了尺寸建议,最后以人机工程虚拟仿真软件CATIA进行验证,分析了司机的视野范围、操作姿势舒适度和手部可达区域。结果表明结合人机工程学相关理论所设计的司机室符合人体舒适度要求,设计中加入了视频监控装置,可降低职业病发生的可能性,司机室尺寸优化结果可为起重机司机室设计提供重要的数据参考。     

Algorithms useful for calculating multi-component equilibria,phase diagrams and other kinds of diagrams

Phase diagrams are important in materials science. They consist of lines separating regions with different sets of stable phases and different kind of axes can be used. Many available phase diagrams are drawn directly from experimental information. However, they are closely related to the thermodynamic properties of the phases and can be calculated from thermodynamic models of the phases using the Calphad technique. This paper presents a set of algorithms to calculate equilibria and several kinds of diagrams using a very flexible set of conditions and axes. The algorithms can be applied to multi-component systems using model parameters in thermodynamic databases.     

TD75-800型花纹皮带运输机的改进

TD75－800型花纹皮带运输机存在粘接工艺不合理、自重大、强度不足等缺陷，经过改进，保证了安全生产，提高了经济效益。